What is Xeljanz®?

Xeljanz® is an inhibitor of Janus kinases (JAKs). It is used to treat moderately to severely active Rheumatoid Arthritis active psoriatic arthritis, and moderately to severely active ulcerative colitis.

What is Xeljanz® Used For?

Xeljanz® is an inhibitor of Janus kinases (JAKs) used to treat adult patients with:

  • Moderately to severely active rheumatoid arthritis who have had an inadequate response or intolerance to methotrexate.
  • Active psoriatic arthritis who have had an inadequate response or intolerance to methotrexate or other disease-modifying antirheumatic drugs (DMARDs).
  • Moderately to severely active ulcerative colitis.

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How Does Xeljanz® Work?

The active substance in Xeljanz®, tofacitinib, acts on enzymes known as Janus Kinases. These enzymes play an important role in the process of inflammation4 that characterizes inflammatory diseases such as rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. By blocking their action, tofacitinib helps reduce inflammation and other symptoms of inflammatory diseases.

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Side Effects of Xeljanz®:

Taking Xeljanz® at too high a dose may increase the risk of death in People With Rheumatoid Arthritis who are 50 and older and have at least 1 risk for heart disease. Those People who may have suffered serious side effects of Xeljanz®. However, your doctor has prescribed this drug because he or she has judged that the benefit to you is greater than the risk of side effects. Careful monitoring by your doctor will lessen the risk.
Tell your doctor right away if you have any signs of infection, including:

  • Fever
  • Chills
  • Persistent Sore Throat
  • Persistent Cough
  • Night Sweats
  • Trouble Breathing
  • Painful/Frequent Urination
  • Warm/Red/Painful Skin

Cautions To Take Xeljanz®:

You should not use Xeljanz® if you have a serious infection. Xeljanz® affects your immune system so please apply caution to take Xeljanz®. You may get infections more easily, even serious or Fatal Infections. Call your doctor if you have a fever, chills, aches, tiredness, cough, trouble breathing, skin sores, diarrhea, weight loss, or burning when you urinate. If you ever had hepatitis B or C, using Xeljanz® can cause this virus to become active or get worse.

Frequently Asked Question

1. Who should not take Xeljanz®?

You should not take Xeljanz® if you have any of the following:

  • active tuberculosis
  • inactive tuberculosis
  • shingles
  • opportunistic fungal infection
  • a bad infection
  • cancer or malignancy
  • high cholesterol
  • anemia
  • low levels of a type of white blood cell called neutrophils
  • a decreased number of lymphocytes in the blood
  • obstruction of a blood vessel by a blood clot
  • diverticulitis
  • liver problems
  • abnormal liver function tests
  • disorder of lymphoid tissue after transplant
  • a mother who is producing milk and breastfeeding
  • malignant lymphoma
  • a rupture in the wall of the stomach or intestine
  • chronic kidney disease stage 3A (moderate)
  • chronic kidney disease stage 3B (moderate)
  • chronic kidney disease stage 4 (severe)
  • chronic kidney disease stage 5 (failure)
  • kidney disease with likely reduction in kidney function
  • an increased risk of developing an uncommon viral infection called an opportunistic infection
  • Child-Pugh class B liver impairment
2. What are the common side effects of Xeljanz®?

The more common side effects of Xeljanz® are:

  • Common cold
  • Diarrhea
  • Headache
  • Upper respiratory infections
  • Rash
  • High cholesterol levels
3. In which form Xeljanz® comes?

Xeljanz® comes in two forms: Xeljanz® and Xeljanz® XR.

4. What if I miss a dose?

If you miss your Xeljanz® dose, let your doctor or pharmacist know about it. Don’t take more than one dose of Xeljanz® at a time on your own.